INSTALL DOSE CALCULATOR
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ENVARSUS® PA dose calculator2

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PWA instructions

ENVARSUS® PA once-daily dose (30% dose reduction):
Input the patient’s total dose of twice-daily IR tacrolimus (mg/day)

Value was not entered.

Please enter a value between 0.51 mg – 50 mg.

Please enter a value between 0.72 mg – 71.42 mg.

Please enter a value between 0.59 mg – 58.82 mg.

dose_calculator.results_table.error_5

Corresponding ENVARSUS® PA tablet combination(s):
ENVARSUS® PA
dose options:*
4 mg tablet 4 mg
1 mg tablet 1 mg
0.75 mg tablet 0.75 mg
ENVARSUS® PA
total dose (mg/day) Once-daily
ENVARSUS® PA
dose (mg/day):
ENVARSUS® PA
dose options:*
Option A - - - -
Option B - - - -
Option C - - - -
Option D - - - -
*Dose calculations have been rounded to an amount that can be achieved with ENVARSUS® PA tablet strengths. Actual dose should be determined and adjusted for each individual to achieve target trough levels.

When switching stable kidney and liver patients from twice-daily IR formulations to once-daily ENVARSUS® PA, adjust the total daily dose.

Titration

Tacrolimus trough levels should be measured prior to the conversion and within a week after the conversion. Dose adjustments should be made to ensure that similar whole blood trough concentrations are maintained after the conversion.

Black African American patients

Clinical studies with ENVARSUS® PA showed that Black African American patients may require a higher dose of ENVARSUS® PA to achieve the desired tacrolimus trough levels.

Please consult the Product Monograph for complete dosing and administration instructions.